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Synthetic mRNA Nanoparticle-Mediated Restoration of p53 Tumor Suppression
With Four Decades of Research, p53 is the Most Studied Transcription Factor Over 50% of Human Cancers Carry Loss of Function Mutations in p53 Synthetic mRNA Delivery of p53 Tumor Suppressor Function...
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mRNA Delivery for Therapeutic Anti-HER2 Antibody In Vivo
mRNAs Encode Heavy and Light Chains of Trastuzumab (Herceptin) Lipid Nanoparticles Deliver the mRNAs Improved Pharmacokinetics and Better Anticancer Activity Achieved Introduction In terms of...
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Aerosol Delivery of Naked mRNA – Part 2
Safe and Effective Intracellular Transport to Respiratory Tract Epithelial Cells Without a Transfection Agent Simply Spray a Water Solution of Naked (Unformulated) mRNA Avoids Formulation in Lipid...
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In Utero Delivery of CleanCap® mRNAs Using Ionizable Lipid Nanoparticles
Advances in Prenatal Diagnostics Set the Stage for Prenatal Therapies In Utero Delivery of Erythropoietin (EPO) Via mRNA Has Now Been Demonstrated Screening Novel Lipid Nanoparticle Carriers Was...
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Chemical Modifications of Adenine Base Editor (ABE) mRNA Expand Its...
The Liu Lab’s ABE Uses an Engineered CRISPR/Cas9 System to Convert a Single “A” in DNA to “G” The Key Component is an Evolved Adenine Deaminase Fused to a ss-DNA Cas9 NickaseABE Efficiency Is Enhanced...
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mRNA Vaccines – A New Era in Vaccinology
Sequence Optimization, Modified Bases, and Delivery are KeyClinicalTrials.Gov Currently Lists 114 Studies of mRNA VaccinesmRNA Vaccine Studies Include 37 Against COVID-19 and 63 Against Various...
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CleanCap® IVT Cas9 mRNA in Micelles Used for Genome Editing in Mouse Brain...
Completely Synthetic Block Co-Polymer Micelles Are Alternatives to Lipid Nanoparticles for Intracellular DeliveryReporter Gene STOP Codon Successfully Knocked Out in Mice Introduction CRISPR-based...
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Four Pillars for Successful Self-Amplifying RNA Vaccines…
Antigen(s)VectorsDeliveryManufacturing And Why They Matter: saRNA vaccines adapt viral RNA amplification mechanisms to induce robust antigen-directed immunitySuccessful saRNA vaccine development...
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Applying CleanCap® mRNA: 4 Example Studies
Airway Tissue Remodeling in Chronic Obstructive Pulmonary DiseaseLocal Gene Delivery to Dermal Fibroblasts for Wound Healing mRNA Replacement Therapies for Cystic FibrosisSecreted Truncated ACE2...
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Four Notable RNA Topics and Themes Rounding out 2021
Vaccinating the World Against COVID-19Karikó and Weissman Become mRNA Vaccine “Rock Stars”What We Know and Don’t Know About COVID-19 First CRISPR-Cas9 Genome Editing in Humans Achieved As 2021 draws...
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